Description

Overview

MOTS-c is a mitochondria-derived peptide that has attracted increasing interest in metabolic and cellular signaling research. Originally identified as a short peptide encoded within mitochondrial DNA, MOTS-c is studied for its involvement in mitochondrial communication with nuclear gene pathways and broader cellular regulatory mechanisms.

Laboratory investigations have examined MOTS-c in the context of metabolic signaling, mitochondrial regulation, and cellular energy sensing systems. Researchers continue to explore how this peptide interacts with pathways associated with cellular adaptation and metabolic regulation within experimental models.

Due to its mitochondrial origin and signaling activity, MOTS-c is frequently studied in laboratories investigating mitochondrial biology and metabolic communication networks.

Research Applications

MOTS-c has been examined in multiple laboratory research settings. These areas of study include:

• Mitochondrial signaling research involving peptides encoded by mitochondrial DNA
• Metabolic pathway investigations exploring cellular energy sensing mechanisms
• Cellular adaptation studies related to metabolic stress responses in experimental models
• Endocrine and metabolic signaling research involving communication between mitochondria and nuclear gene expression
• Cellular regulation studies examining how mitochondrial peptides influence intracellular signaling pathways

These applications reflect ongoing laboratory interest in the role of mitochondria-derived peptides in cellular communication networks.

Mechanism and Pathway Context

Research has investigated the role of MOTS-c in signaling pathways that connect mitochondrial activity with nuclear gene expression. As a mitochondria-encoded peptide, MOTS-c has been explored in laboratory models studying mitochondrial-to-nuclear communication mechanisms.

Studies have examined its interaction with cellular energy sensing pathways and regulatory signaling networks involved in metabolic adaptation. Experimental models have also explored its potential involvement in pathways associated with AMP-activated protein kinase (AMPK) signaling and other cellular regulatory mechanisms.

These investigations focus on understanding how mitochondrial peptides participate in broader intracellular communication systems that regulate cellular responses to environmental and metabolic conditions.

Research Summary

MOTS-c was first identified as a short peptide encoded within the mitochondrial genome, distinguishing it from many other peptides that originate from nuclear DNA. Its discovery introduced a new area of research focused on mitochondria-derived signaling peptides.

Since its identification, laboratory research has explored several areas related to MOTS-c activity, including mitochondrial signaling, metabolic regulation pathways, and cellular communication networks between mitochondria and the nucleus.

Scientific investigations continue to examine how this peptide participates in regulatory pathways that influence cellular energy sensing and metabolic signaling within controlled research environments.

Product Specifications

• Peptide Name: MOTS-c
• Amount per vial: 10 mg
• Purity: ≥99%
• Physical form: Lyophilized powder
• Research classification: Mitochondria-derived research peptide
• Manufacturing: Research-grade peptide synthesis
• Intended use: Laboratory research applications

Storage and Handling

For laboratory stability, this peptide should be stored refrigerated after reconstitution.
Lyophilized material should be stored in a cool, dry environment until prepared for laboratory research use.

Proper laboratory handling procedures should be followed when working with research peptides.

Research Use Disclaimer

FOR RESEARCH USE ONLY.
This product is intended strictly for laboratory research purposes. It is not intended for human or veterinary use.

Scientific Background

MOTS-c is a mitochondrial-derived peptide discovered through investigations of the mitochondrial genome. Unlike many peptides encoded by nuclear DNA, MOTS-c originates from mitochondrial DNA and represents a class of peptides sometimes referred to as mitochondrial-derived peptides.

The identification of MOTS-c expanded scientific interest in how mitochondria contribute not only to energy production but also to cellular signaling and regulatory functions. Research has focused on understanding how mitochondrial peptides participate in communication between mitochondria and nuclear gene pathways.

This emerging field has opened new avenues of investigation into mitochondrial signaling biology and metabolic regulation mechanisms.

Key Research Areas

Metabolic Pathway Research

Laboratory studies have explored MOTS-c within metabolic signaling frameworks that investigate how cells respond to energy availability and metabolic stress.

Mitochondrial Biology Research

As a peptide encoded by mitochondrial DNA, MOTS-c has been studied in experimental models examining mitochondrial communication and regulatory signaling networks.

Cellular Regulation Research

Investigations have examined how mitochondrial peptides may influence cellular regulatory pathways and intracellular signaling systems that coordinate cellular responses to environmental changes.

Endocrine and Signaling Research

Researchers have also explored the relationship between mitochondrial signaling peptides and broader metabolic regulatory systems within experimental laboratory environments.

Pathway Interaction Overview

Research has examined MOTS-c in the context of cellular pathways associated with energy sensing and metabolic signaling. Experimental models have explored its interaction with regulatory networks involving mitochondrial communication with nuclear transcription mechanisms.

Studies have also investigated how mitochondrial-derived peptides participate in intracellular signaling pathways associated with cellular adaptation to metabolic conditions.

These ongoing investigations contribute to the growing understanding of mitochondrial peptides and their role in cellular regulatory systems.

Literature Overview

Scientific literature examining MOTS-c primarily focuses on mitochondrial peptide signaling and metabolic regulatory pathways. Research publications have investigated how mitochondria-encoded peptides participate in cellular communication networks and influence metabolic signaling in laboratory models.

Ongoing studies continue to expand understanding of mitochondrial peptide biology and the potential regulatory functions of peptides derived from mitochondrial DNA.

References

Research regarding MOTS-c can be explored through scientific databases and publications including:

1. Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. 2015;21(3):443-454. PMID: 25738459.
2. Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. 2021;12(1):470. PMID: 33473122.
3. Kim SJ, Xiao J, Wan J, Cohen P, Yen K. Mitochondrially derived peptides as novel regulators of metabolism. Journal of Physiology. 2017;595(21):6613-6621. PMID: 28574161.
4. Lu H, Tang S, Xue C, et al. Mitochondrial-derived peptide MOTS-c increases adipose thermogenic activation to promote cold adaptation. International Journal of Molecular Sciences. 2019;20(10):2456. PMID: 31108872.

Researchers interested in this compound are encouraged to review the growing body of literature surrounding mitochondrial peptide signaling and metabolic pathway investigations